检索结果(检索关键词为:灵长类;结果共88条)
  • 陈乾生
    实验动物科学与管理 2003年第S1期 DOI:
    关键词: 非灵长类;;动物福利
    摘要: While comparing non human primates with human beings, it is not hard to conclude certain similarities between these two based on aspects such as morphological anatomy, biochemistry functioning and so on. As a result, non human primates often play an important role in life scientific researches. These primates are always used as “Stand Ins" for human beings. In the processes of toxicological testing of new drugs, some drugs, especially drugs of genic projects or biological medicines are requiring uses of primates as part of the new drug testing. Therefore, the morality and ethics of using non human primates have to be emphasised by people. After all, this is one of the issues that concerns with the expectations of meeting the international scientific research standards by our national laboratory animal sciences. In fact, the moral and ethical problems of non human primates experiments is related to the matters of animal welfares. What is so called “Animal Welfare"? One Taiwanese researcher Xia Liang Zhou (1990) has concluded the application of animal welfare as such: “To treat the alive animals better, and to reduce their pain of dies." Actually, this has summarised the animal welfares throughout the life of an animal. At the current stage, the principals of the Law of International Animal Welfare lay emphasis on ensuring 5 basic freedoms of animals, which include:1. Freedom of NOT suffering hunger and thirst;2. Freedom of having comfortable lives;3. Freedom of NOT suffering hurts, pains and diseases;4. Freedom of NOT being scared;5. Freedom of expressing its nature. The International Fund For Animal Welfare (IFAW) is the largest animal welfare organisation around the globe. There is an operational branch of this organisation in Beijing, China. This organisation aims to stand for the animals' rights to life, to promote the wild animal protections, and to support the practices of 3R (i.e. Replacement, Reduction and Refinement) of animal experiments by scientific researchers. These are all correct opinions and steps; especially researchers of the non human primate experiments should treat the animals better and improve the qualities of scientific researches. How to treat the animals better in the processes of non human primate experiments? According to our experiences and practices, it should mainly include the following aspects:1. To provide comfortable living environments for the animals. One should also try to meet and fulfil the natural environment, even temperatures and moisture levels, required by the animals. Certain degree of activity spaces should be available. The sizes of feeding cages are required to meet the standards. In particular, cages cannot be undersized, which might bring stresses to the animals. 2. To provide feeds with enough nutrition, as well as clean drinkable water. One should pay special attentions to the feeding of animals during the experiment processes.3. While catching and securing primates, one should handle the animals gently and carefully without hurting the animals. Ataractics and/or narcotics could be applied accordingly, in order to reduce the pain of animals for the durations of the operations.4. After the experiments of non human primates, unless pathological anatomies are essential to obtain necessary data, one should try to reduce the quantity of animal killing. Using isolated natural islands to set the tested animals free would be a preferable way. If killing of animals is unavoidable, euthanasia is more desirable to reduce the pain of dying.5. To set up “Animal Tomb" to mourn for the contributions and sacrifices of laboratory animals for the improvements of science.

  • 江鹏亮; 汤球; 余琛琳; 崔淑芳
    实验动物科学 2010年第27卷第6期 DOI:
    关键词: 非人灵长类;;模型;;医学研究
    摘要: 1非人灵长类动物的生物学特点1.1动物分类学位置猕猴(Macaca mulatta)属于哺乳纲、灵长目、猴科、猕猴属动物。猕猴实际上是猕猴属猴的总称,共有12个种、46个亚种。分布于我国的有5个种,包括恒河猴、熊猴、红面断尾猴、台湾岩猴和平顶猴。

  • 季芳; 万玉玲; 徐强; 饶军华; 刘晓明
    实验动物科学 2008年第5期 DOI:
    关键词: 非人灵长类;;自伤行为;;动物福利
    摘要:

  • 刘岩; 张然; 马腾; 张运海; 何祖勇; 朱化彬; 李宁
    实验动物科学 2011年第28卷第2期 DOI:
    关键词: 转基因;;家畜;;非人灵长类;;疾病模型
    摘要: 转化医学研究领域,基础研究的新发现推进到临床应用是一个耗时、低效并且花费巨大的过程;新药开发过程需要优化各种经济和伦理因素,在合理时间范围内为病人提供对症治疗。适当的动物模型,是新药及新治疗策略的研发、有效性和安全性评价的重要媒介,是研究成功转化的关键[1]。转基因

  • 姚紫彤; 王舒波; 卢静; 陈柏安
    实验动物科学 2016年第33卷第6期 DOI:
    关键词: 阿尔茨海默病;;致病基因;;AD动物模型;;非人灵长类动物
    摘要: 我国现有阿尔茨海默病(AD)患者800-1000万,患者数量随着人口老龄化逐年增加,目前尚无有效治疗或者逆转AD的药物和方法。过去基于啮齿类动物模型筛选出的用于治疗AD的药物在人体试验中均疗效差或有严重的副作用,这与啮齿类动物模型和AD患者病理及行为特征差异大有直接关系。非人灵长类动物与人的大脑和神经系统高度相似,建立AD非人灵长类动物模型意义重大。AD病因复杂,但是致病基因突变是其已知的明确病因,应该重视利用基因修饰或者基因筛选等技术建立AD非人灵长类动物模型。本文将着重介绍AD致病基因突变相关的转基因小鼠模型和非人灵长类动物模型的特点和现状。